kinesin family 5A (Kif5a, neuronal kinesin heavy chain, NKHC, kinesin heavy chain isoform 5A, kinesin heavy chain neuron-specific 1, KIF5A, NKHC1)
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Introduction
Kinesin heavy chain, distributed throught CNS, concentrated in perinuclear regions.
Function
- kinesin heavy chain
- interacts with GRIP1 (putative)
Structure
- composed of 3 structural domains:
- a large globular N-terminal domain, responsible for the motor activity of kinesin (it hydrolyzes ATP & binds microtubule)
- a central alpha-helical coiled coil domain that mediates the heavy chain dimerization
- a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles & membranous organelles
- belongs to the kinesin-like protein family, kinesin subfamily
- contains 1 kinesin-motor domain
Compartment
- cytoplasm, perinuclear region
- concentrated in the cell body of the neurons, particularly in the perinuclear region (putative)
Expression
Pathology
- defects in KIF5A are the cause of spastic paraplegia type-10