small nuclear ribonucleoprotein Sm D1; Sm-D1; Sm-D autoantigen; snRNP core protein D1 (SNRPD1)

Function

• may act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA
• methylated on Arg by PRMT5 & PRMT7
• methylation is required for assembly & biogenesis of snRNPs
• identified in the spliceosome C complex
• component of the U11/U12 snRNPs that are part of the U12-type spliceosome

Structure

belongs to the snRNP core protein family

Compartment

nucleus

Pathology

• anti Sm antibodies are found in patients with systemic lupus erythematosus

More general terms

• Sm (Smith) protein/antigen

Component of

• spliceosome C complex
• U12-type spliceosome (minor spliceosome)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6632
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6632
• OMIM: https://mirror.omim.org/entry/601063
• UniProt: http://www.uniprot.org/uniprot/P62314.html