tripartite motif-containing protein 39; RING finger protein 23; testis-abundant finger protein (TRIM39, RNF23, TFP)

Function

• may facilitate apoptosis by inhibiting the poly-ubiquitination & subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1
• interacts with MOAP1

Structure

• belongs to the TRIM/RBCC family
• contains 1 B box-type Zn+2 finger
• contains 1 B30.2/SPRY domain
• contains 1 RING-type Zn+2 finger

Compartment

• cytoplasm, cytosol, mitochondrion
• found predominantly in the cytosol
• partial shift from the cytosol to the mitochondria when co-localized with MOAP1

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen & testis

More general terms

• tripartite motif-containing protein (trim protein)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56658
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56658
• OMIM: https://mirror.omim.org/entry/605700
• UniProt: http://www.uniprot.org/uniprot/Q9HCM9.html