tripartite motif-containing protein 14 (TRIM14, KIAA0129)

Function

• inhibits the transcriptional activity of SPI1 in a dose- dependent manner (putative)
• interacts with SPI1 (putative)

Structure

• the B-box Zn+2 finger is responsible for inhibition of SPI1-mediated transcriptional activation (putative)
• belongs to the TRIM/RBCC family
• contains 1 B box-type Zn+2 finger
• contains 1 B30.2/SPRY domain

Alternative splicing

named isoforms=2; alpha, beta

Expression

• highest expression in liver
• undetectable in skeletal muscle

More general terms

• tripartite motif-containing protein (trim protein)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9830
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9830
• OMIM: https://mirror.omim.org/entry/606556
• UniProt: http://www.uniprot.org/uniprot/Q14142.html