tripartite motif-containing protein 3; RING finger protein 22; brain-expressed RING finger protein; RING finger protein 97 (TRIM3, BERP, RNF22, RNF97)

Function

• probably involved in vesicular trafficking via its association with the CART complex
• associates with myosin-Vb (MYO5B) & alpha-actinin-4 (ACTN4) (putative)

Structure

• interaction with MYO5B is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing 6 blades (putative)
• belongs to the TRIM/RBCC family
• contains 1 B box-type Zn+2 finger
• contains 1 filamin repeat
• contains 6 NHL repeats
• contains 1 RING-type Zn+2 finger

Compartment

• cytoplasm (putative)
• early endosome

Alternative splicing

named isoforms=3; alpha, beta, gamma

Expression

• expressed in brain, heart, uterus & testis

More general terms

• tripartite motif-containing protein (trim protein)
• phosphoprotein

Component of

• CART complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10612
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10612
• OMIM: https://mirror.omim.org/entry/605493
• UniProt: http://www.uniprot.org/uniprot/O75382.html