gamma-crystallin D; gamma-D-crystallin; gamma-crystallin 4 (CRYGD, CRYG4)

Function

• crystallins are the dominant structural components of the vertebrate eye lens

Structure

• monomer (putative)
• has a two-domain beta-structure, folded into four very similar greek key motifs
• belongs to the beta/gamma-crystallin family
• contains 4 beta/gamma crystallin greek key domains

Pathology

• defects in CRYGD are a cause of autosomal dominant cataract
• defects in CRYGD are the cause of
  • polymorphic congenital cataract
  • congenital cerulean cataract type 3
  • crystalline aculeiform cataract

Genetics

• 90% of the gamma crystallins synthesized in young humans are products of the gamma-G3 & gamma-G4 genes

More general terms

• gamma-crystallin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1421
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1421
• OMIM: https://mirror.omim.org/entry/115700
• OMIM: https://mirror.omim.org/entry/123690
• OMIM: https://mirror.omim.org/entry/601286
• OMIM: https://mirror.omim.org/entry/604219
• OMIM: https://mirror.omim.org/entry/608983
• UniProt: http://www.uniprot.org/uniprot/P07320.html