gamma-crystallin C; gamma-C-crystallin; gamma-crystallin 2-1; gamma-crystallin 3 (CRYGC, CRYG3)

Function

• crystallins are the dominant structural components of the vertebrate eye lens

Structure

• monomer (putative)
• has a two-domain beta-structure, folded into four very similar greek key motifs
• belongs to the beta/gamma-crystallin family contains 4 beta/gamma crystallin greek key domains

Pathology

• mutations associated with:
  • autosomal dominant cataracts
  • Coppock-like cataract (CCL)

Genetics

• 90% of the gamma crystallins synthesized in young humans are products of the gamma-G3 & gamma-G4 genes

More general terms

• gamma-crystallin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1420
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1420
• OMIM: https://mirror.omim.org/entry/123680
• OMIM: https://mirror.omim.org/entry/604219
• OMIM: https://mirror.omim.org/entry/604307
• UniProt: http://www.uniprot.org/uniprot/P07315.html