peptidyl-prolyl cis-trans isomerase-like 2 (PPIase, rotamase, ryclophilin-60, cyclophilin-like protein Cyp-60, PPIL2)

Function

• accelerate the folding of proteins.
• catalyzes cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Peptidylproline (omega=180) <--> peptidylproline (omega=0)

Structure

• contains 1 PPIase cyclophilin-type domain
• contains 1 U-box domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• widely expressed
• expressed in thymus, pancreas, testis >> brain, leukocytes

Pathology

• expressed in most lymphomas & melanomas

More general terms

• cyclophilin

Database

• OMIM: https://mirror.omim.org/entry/607588
• UniProt: http://www.uniprot.org/uniprot/Q13356.html