FK506-binding protein 6 (36 kD FK506-binding protein, immunophilin FKBP36, FKBP6)

Function

• PPIases accelerate the folding of proteins

peptidylproline (omega=180) <--> peptidylproline (omega=0)

Structure

• contains 1 PPIase FKBP-type domain
• contains 3 TPR repeats

Expression

• detected in all tissues examined
• higher expression in testis, heart, skeletal muscle, liver, & kidney

Pathology

• haploinsufficiency of FKBP6 may be associated with cardiovascular & musculo-skeletal abnormalities observed in Williams-Beuren syndrome

More general terms

• FK506 binding protein (FKBP)

Database

• UniProt: http://www.uniprot.org/uniprot/O75344.html
• OMIM: https://mirror.omim.org/entry/194050
• OMIM: https://mirror.omim.org/entry/604839