thymidine kinase, cytosolic (TK1)

Function

• phosphorylated on Ser-13 in mitosis

ATP + thymidine = ADP + thymidine 5'-phosphate

Structure

• homotetramer
• belongs to the thymidine kinase family

Compartment

cytoplasm

Expression

• activity is high in proliferating cells & peaks during the S-phase of the cell cycle
• activity is very low in resting cells

Notes

• two forms have been identified in animal cells, one in cytosol & one in mitochondria

More general terms

• thymidine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7083
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7083
• OMIM: https://mirror.omim.org/entry/188300
• UniProt: http://www.uniprot.org/uniprot/P04183.html