diacylglycerol kinase alpha; DAG kinase alpha; 80 kD diacylglycerol kinase; diglyceride kinase alpha; DGK-alpha (DGKA, DAGK, DAGK1)

Function

• upon cell stimulation, converts the second messenger diacylglycerol into phosphatidate, initiating resynthesis of phosphatidylinositols & attenuating protein kinase C activity
• stimulated by Ca+2 & phosphatidylserine
• phosphorylated by protein kinase C

ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

Structure

• monomer
• belongs to the eukaryotic diacylglycerol kinase family
• contains 1 DAGKc domain
• contains 2 EF-hand domains
• contains 2 phorbol-ester/DAG-type Zn+2 fingers

Alternative splicing

named isoforms=2

Expression

lymphocytes & oligodendroglial cells

More general terms

• diacylglycerol kinase
• zinc finger protein
• Ca+2 binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1606
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1606
• OMIM: https://mirror.omim.org/entry/125855
• UniProt: http://www.uniprot.org/uniprot/P23743.html