pantothenate kinase 4 (hpanK4, PANK4)

Function

• role in physiological regulation of intracellular CoA (putative)
• interacts with PKM2 (putative)
• regulated by feedback inhibition by CoA & its thioesters (putative)
• cofactor biosynthesis, coenzyme A biosynthesis
• coenzyme A from pantothenate: step 1/5

 ATP + (R)-pantothenate <--> ADP + (R)-4'-phosphopantothenate

Structure

belongs to the type 2 pantothenate kinase family

Compartment

cytoplasm (probable)

Expression

• ubiquitously expressed with higher expression in muscle

More general terms

• pantothenate kinase

Database

• OMIM: https://mirror.omim.org/entry/606162
• UniProt: http://www.uniprot.org/uniprot/Q9NVE7.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55229