beta-1,3-galactosyltransferase 3; beta-1,3-GalTase 3; beta3Gal-T3; b3Gal-T3; galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase; UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase; globoside synthase; beta-3-Gx-T3 (B3GALT3, B3GALNT1)

Function

• transfers N-acetylgalactosamine to globotriaosylceramide

Cofactor: Mg+2

Compartment

Golgi apparatus

Expression

• expressed in heart, brain > lung, placenta, kidney, testis > liver, spleen, stomach
• no expression in skeletal muscle

Polymorphism

• different combinations or absence of the P blood group antigens define 5 different phenotypes: P1, P2, P1(k), P2(k), P
• genetic variation in B3GALT3 determines P1(k) & P2(k) phenotype
  • rare
  • lack ability to synthesize P antigen identified as globoside

More general terms

• galactosyltransferase

Database

• OMIM: https://mirror.omim.org/entry/111400
• OMIM: https://mirror.omim.org/entry/603094
• UniProt: http://www.uniprot.org/uniprot/O75752.html