glycogenin-2; GN-2; GN2 (GYG2)

Function

• self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase
• glycan biosynthesis; glycogen biosynthesis
• self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-228
• homodimer, tightly complexed to glycogen synthase

Cofactor:

• divalent metal ions required for self-glucosylation
• Mn+2 is the most effective

UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin

Structure

belongs to the glycogenin family

Alternative splicing

• named isoforms=6; alpha, beta, gamma, delta, epsilon, Zeta
• additional isoforms seem to exist

Expression

• expressed preferentially in liver, heart, & pancreas

More general terms

• glycogenin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8908
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8908
• OMIM: https://mirror.omim.org/entry/300198
• UniProt: http://www.uniprot.org/uniprot/O15488.html