adenine phosphoribosyltransferase (APRT)

Function

• catalyzes a salvage reaction resulting in the formation of AMP (salvage is energically less costly than de novo synthesis)
• purine metabolism; AMP biosynthesis via salvage pathway
• AMP from adenine: step 1/1

AMP + diphosphate
   <-->
adenine + 5-phospho-alpha-D-ribose 1-diphosphate

Structure

• homodimer
• belongs to the purine/pyrimidine phosphoribosyltransferase family

Compartment

cytoplasm

Pathology

• defects in APRT are the cause of APRT deficiency

Laboratory

• adenine phosphoribosyltransferase in amniotic fluid cells
• adenine phosphoribosyltransferase in chorionic villus
• adenine phosphoribosyltransferase in erythrocytes
• adenine phosphoribosyltransferase in serum/plasma
• adenine phosphoribosyltransferase in trophoblasts

More general terms

• phosphoribosyltransferase

More specific terms

• cleavage & polyadenylation specificity factor (CPSF) complex

Database

• UniProt: http://www.uniprot.org/uniprot/P07741.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:353
• OMIM: https://mirror.omim.org/entry/102600
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=353