multiple inositol polyphosphate phosphatase 1; inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; ins(1,3,4,5)P(4) 3-phosphatase (MINPP1 MIPP UNQ900/PRO1917)

Function

• phosphoinositide 5-phosphatase & phosphoinositide 6-phosphatase
• regulates cellular levels of inositol pentakisphosphate (InsP5) & inositol hexakisphosphate (InsP6)
• may play a role in bone development (endochondral ossification)

Compartment

endoplasmic reticulum lumen

Alternative splicing

named isoforms=3

Expression

• widely expressed
• highest levels in kidney, liver, placenta

Pathology

• defects in MINPP1 may be involved in follicular thyroid adenoma development

More general terms

• phosphomonoesterase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9562
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9562
• OMIM: https://mirror.omim.org/entry/605391
• UniProt: http://www.uniprot.org/uniprot/Q9UNW1.html