deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; dUTP nucleotidase; dUTPase; dUTP pyrophosphatase (DUT)

Function

• role in nucleotide metabolism
• produces dUMP, the immediate precursor of thymidine nucleotides
• decreases intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
• phosphorylation is necessary for activity
• pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2
• phosphorylation in mature T-cells is cell cycle-dependent

dUTP + H2O <-->  dUMP + diphosphate

Cofactor: Mg+2

Structure

belongs to the dUTPase family

Compartment

• isoform 1: mitochondrion
• isoform 2: nucleus

Alternative splicing

named isoforms=3

Expression

found in a variety of tissues

More general terms

• nucleotidase
• pyrophosphatase (diphosphohydrolase)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1854
• OMIM: https://mirror.omim.org/entry/601266
• UniProt: http://www.uniprot.org/uniprot/P33316.html