11-cis retinol dehydrogenase (11-cis RDH, RDH5, RDH1)
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Function
- stereospecific 11-cis retinol dehydrogenase
- catalyzes the final step in the biosynthesis of 11-cis retinaldehyde
- retinoic acid biosynthesis, 1st (rate-limiting) step
retinol + NAD+ <--> retinal + NADH
Structure
- belongs to the short-chain dehydrogenases/reductases (SDR) family
Compartment
membrane
Expression
Pathology
- defects in RDH5 are a cause of fundus albipunctatus
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q92781.html
- ↑ Mutations of the RDH5 gene Retina International's Scientific Newsletter http://www.retina-international.com/sci-news/rdhmut.htm