1,25-dihydroxyvitamin D3 24-hydroxylase, mitochondrial; vitamin D3 24-hydroxylase; 24-OHase; cytochrome P450 24A1; P450-CC24 (CYP24A1, CYP24)
Jump to navigation
Jump to search
Function
- role in maintaining Ca+2 homeostasis
- catalyzes NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D3) & calcitriol
- the enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid
- also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D3-26,23-lactone
calcitriol + NADPH + O2 <--> calcitetrol + NADP+ + H2O
calcidiol + NADPH + O2 <--> secalciferol + NADP+ + H2O
Cofactor: heme group (putative)
Structure
belongs to the cytochrome P450 family