beta-crystallin B3; beta-B3 crystallin (CRYBB3 CRYB3)
Jump to navigation
Jump to search
Function
- crystallins are the dominant structural components of the vertebrate eye lens
- homodimer/heterodimer, or complexes of higher order
- the structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (putative)
Structure
- has a two-domain beta-structure, folded into four very similar greek key motifs
- belongs to the beta/gamma-crystallin family
- contains 4 beta/gamma crystallin greek key domains
Pathology
- defects in CRYBB3 are the cause of cataract congenital nuclear autosomal recessive type 2