beta-crystallin A4; beta-A4 crystallin (CRYBA4)
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Function
- crystallins are the dominant structural components of the vertebrate eye lens
- homodimer/heterodimer, or complexes of higher order
- the structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (putative)
Structure
- has a two-domain beta-structure, folded into four very similar greek key motifs
- belongs to the beta/gamma-crystallin family
- contains 4 beta/gamma crystallin greek key domains
Pathology
- defects in CRYBA4 are the cause of cataract zonular type 2
- defects in CRYBA4 are a cause of microphthalmia isolated with cataract type 4
More general terms
References
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1413
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1413
- OMIM: https://mirror.omim.org/entry/123631
- OMIM: https://mirror.omim.org/entry/610425
- OMIM: https://mirror.omim.org/entry/610426
- UniProt: http://www.uniprot.org/uniprot/P53673.html