beta-1,4-galactosyltransferase 4; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4 (B4GALT4)

Function

• role in glycosylation
• synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids
• protein modification; protein glycosylation

UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine

Cofactor: Mn+2 (putative)

Kinetic parameters:

• KM=238 uM for GlcNAc-B-S-pNP

Structure

belongs to the glycosyltransferase 7 family

Compartment

• Golgi stack membrane
• trans cisternae of Golgi stack

Expression

• high expression in heart, placenta, kidney & pancreas
• lower in brain, colon, lung, muscle, ovary, testis & uterus

More general terms

• beta-1,4-galactosyltransferase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8702
• OMIM: https://mirror.omim.org/entry/604015
• UniProt: http://www.uniprot.org/uniprot/O60513.html