beta-1,4-galactosyltransferase 3; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3 (B4GALT3)
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Function
- role in glycosylation
- synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids
- protein modification; protein glycosylation
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide => UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D- glucosaminylglycopeptide UDP-galactose + N-acetyl-D-glucosamine => UDP + N-acetyllactosamine
Cofactor: Mn+2 (putative)
Kinetic parameters:
- KM=63 uM for GlcNAc-B-S-pNP
Structure
belongs to the glycosyltransferase 7 family
Compartment
Alternative splicing
named isoforms=2
Expression
- found in various tissues
- highest expression in placenta, prostate, testis, ovary, intestine & muscle, & in fetal brain
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/O60512.html
- ↑ GGDB; Note: glycogene database http://ggdb.muse.aist.go.jp/GGDB/index.jsp