cAMP-specific 3',5'-cyclic phosphodiesterase 4C; DPDE1; PDE21 (PDE4C, DPDE1)

Function

• hydrolyzes the second messenger cAMP
• purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1

adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate

Cofactor:

• binds 2 divalent metal cations per subunit
• site 1 may preferentially bind Zn+2
• site 2 has a preference for Mg+2 &/or Mn+2

Inhibition:

• inhibited by rolipram

Structure

• belongs to the cyclic nucleotide phosphodiesterase family, PDE4 subfamily

Alternative splicing

• named isoforms=7; PDE4C1, PDE4C2, PDE4C3, PDE4C4, PDE4C5. PDE4C6, PDE4C7

Expression

• expressed in various tissues
• not expressed in cells of the immune system

More general terms

• phosphodiesterase 4; cAMP specific phosphodiesterase (PDE4)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5143
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5143
• OMIM: https://mirror.omim.org/entry/600128
• UniProt: http://www.uniprot.org/uniprot/Q08493.html