DIS3-like exonuclease 2 (DIS3L2)

Function

probable exonuclease (putative)

Structure

belongs to the ribonuclease II (RNB) family

Alternative splicing

named isoforms=5

Pathology

• DIS3L2 gene is disrupted by a chromosomal translocation t(2;7)(q37.1;q21.3) found in a patient suffering from Marfanoid habitus & skeletal anomalies
• however, its absence does not seem to be the cause of the disease

More general terms

• exonuclease

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1295
• UniProt: http://www.uniprot.org/uniprot/Q8IYB7.html