ribonuclease UK114 (14.5 kD translational inhibitorcprotein, p14.5, UK114 antigen homolog, HRSP12, PSP)

Function

• endoribonuclease
• inhibition of translation by cleaving mRNA
• inhibits cell-free protein synthesis
• cleaves phosphodiester bonds only in single-stranded RNA
• up-regulated during cellular differentiation

Structure

homotrimer

Compartment

• cytoplasm, nucleus
• mostly cytoplasmic but, in less differentiated cells occasionally nuclear

Expression

• expressed in renal distal tubular epithelial cells, hepatocytes
• weak expression in other tissues

More general terms

• endoribonuclease

Database

• OMIM: https://mirror.omim.org/entry/602487
• UniProt: http://www.uniprot.org/uniprot/P52758.html