ribonuclease-H1 (ribonuclease H type II, RNASEH1, RNH1)

Function

• degrades the RNA of RNA-DNA hybrids specifically
• endonucleolytic cleavage to 5'-phosphomonoester
• in the presence of Mg+2, Mn+2 is inhibitory

Cofactor:

• binds 1 Mg+2 per subunit
• may bind a 2nd metal ion at a regulatory site, or after substrate binding

Structure

• monomer (probable)
• belongs to the Rnase H family
• contains 1 Rnase H domain

Compartment

cytoplasm (putative)

Expression

ubiquitous

More general terms

• ribonuclease-H

Database

• OMIM: https://mirror.omim.org/entry/604123
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=246243
• UniProt: http://www.uniprot.org/uniprot/O60930.html