chromosomal translocation t6q27:8q11

Introduction

Chromosomal translocation t(6;8)(q27;p11) with FGFR1OP with FGFR1 may be a cause of stem cell myeloproliferative disorder. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity responsible for the transforming activity.

More general terms

• chromosomal translocation

Additional terms

• myelodysplastic syndrome (MDS)