protein URG4; HBV X protein up-regulated gene 4 protein; HBxAg up-regulated gene 4 protein (URG4, URGCP, KIAA1507)

Function

• may be involved in cell cycle progression through the regulation of cyclin D1 expression

Compartment

• cytoplasm. nucleus
• in epithelial cells localized predominantly in the cytoplasm & occasionally in nuclei

Alternative splicing

named isoforms=3

Expression

• induced by HBxAg

Pathology

• strongly expressed in hepatitis B-infected liver & in hepatocellular carcinoma
• highly expressed in well-differentiated gastric cancer tissues & various gastric cancer cell lines
• may participate in the development of hepatocellular carcinoma by promoting hepatocellular growth & survival
• may play an important role in development of gastric cancer

More general terms

• uncharacterized protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8TCY9.html