protein IMPACT (imprinted & ancient gene protein homolog, IMPACT)

Function

• translational regulator that ensures constant high levels of translation under amino acid starvation
• acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) & subsequent down-regulation of protein synthesis (putative)
• interacts with GCN1/GCN1L1 (putative)

Structure

• belongs to the IMPACT family
• contains 1 RWD domain

Alternative splicing

named isoforms=2

Expression

• widely expressed
• xpressed at high level in brain

Genetics

• in contrast to the mouse or rabbit ortholog, the IMPACT locus is not imprinted in human

More general terms

• uncharacterized protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5536
• UniProt: http://www.uniprot.org/uniprot/Q9P2X3.html