Sorting nexin-20 (selectin ligand-interactor cytoplasmic 1, SNX20, SLIC1)

Function

• serves as a sorting protein that cycles P-selectin glycoprotein ligand 1 (PSLG1) into endosomes with no impact on leukocyte recruitement
• interacts with SELPLG

Structure

• PX domain binds phosphatidylinositol 3-phosphate which is necessary for localization to the endosomes
• belongs to the sorting nexin family
• contains 1 PX (phox homology) domain

Compartment

cell membrane, cytoplasm, nucleus, endosome

Alternative splicing

named isoforms=4

More general terms

• uncharacterized protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1244
• UniProt: http://www.uniprot.org/uniprot/Q7Z614.html