developmental pluripotency-associated 5 protein (hDPPA5, embryonal stem cell-specific gene 1 protein, Esg-1, DPPA5, ESG1)

Function

• role in the maintenance of embryonic stem (ES) cells pluripotency
• dispensable for self-renewal of pluripotency ES cells & establishment of germ cells
• associates with specific target mRNAs (putative)

Structure

contains 1 KH domain

Compartment

cytoplasm (putative)

Expression

• expressed in primordial germ (PGC), embryonic germ (EGC) & embryonic stem (ESC) cells
• not detected in embryonic carcinoma (ECC) cells
• down-regulated in differentiated embryonic stem cells (ESC), compared with strong expression in undifferentiated ESC cells

More general terms

• uncharacterized protein

Database

• UniProt: http://www.uniprot.org/uniprot/A6NC42.html