protein NLRC3 (nucleotide-binding oligomerization domain protein 3, caterpiller protein 16.2, CLR16.2, CARD15-like protein, NLRC3, NOD3)

Function

• may modulate T-cell activation
• decreases the transcription of genes that are normally up-regulated after T-cell stimulation
• delays degradation of NFKBIA/IKBA

Structure

• belongs to the NLRP family
• contains 17 LRR repeats (leucine-rich repeats)
• contains 1 NACHT domain

Compartment

cytoplasm

Alternative splicing

named isoforms=4

Expression

• detected in peripheral blood mononuclear cells
• down-regulated upon T-cell activation

More general terms

• uncharacterized protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q7RTR2.html