Ich-1 protease (caspase-2), suppressive or short isoform

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[1][2]

Introduction

Ich-1L apparently promotes apoptosis, while ich-1S inhibits it. Ich-1S lacks the region of ich-1L homologous to p10 of ICE.

More general terms

References

  1. ↑ Wang L, Miura M, Bergeron L, Zhu H, Yuan J. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell. 1994 Sep 9;78(5):739-50. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8087842
  2. ↑ Kumar S. ICE-like proteases in apoptosis. Trends Biochem Sci. 1995 May;20(5):198-202. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7610484
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