2'-5'-oligoadenylate synthase 2; (2-5')oligo(A) synthase 2; 2-5A synthase 2; p69 OAS / p71 OAS; p69OAS / p71OAS (OAS2)

Function

• may play a role in mediating resistance to virus infection, control of cell growth, differentiation, & apoptosis
• binds double-stranded RNA & polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent Rnase-L that, when activated, cleaves single-stranded RNAs

Structure

• homodimer
• belongs to the 2-5A synthase family

Compartment

• mitochondria, nucleus, microsome. endoplasmic reticulum
• associated with different subcellular fractions such as mitochondrial, nuclear, & rough/smooth microsomal fractions

Alternative splicing

named isoforms=2

Expression

induced by interferons

More general terms

• 2'5'-oligoadenylate synthetase
• myristoylated protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4939
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4939
• OMIM: https://mirror.omim.org/entry/603350
• UniProt: http://www.uniprot.org/uniprot/P29728.html