acute hypersensitivity pneumonitis

Etiology

• Micropolyspora faeni
• Thermoactinomyces vulgaris

Pathology

• biopsy may show bronchiolitis obliterans with organizing pneumonia (BOOP)

Clinical manifestations

• symptoms appear 4-6 hours after exposure
  • fever/ chills
  • sweats
  • dry cough
  • dyspnea
  • tachypnea
  • basal crackles
  • no wheezing
• symptoms resulve within 18-24 hours but recur on re-exposure

Laboratory

• leukocytosis
• hypergammaglobulinemia
• serology: precipitating antibody
• biopsy is rarely indicated

Radiology

• chest X-ray
  • increased bronchovascular markings
  • fine reticular & nodular defects

More general terms

• hypersensitivity pneumonitis

Additional terms

• bronchiolitis obliterans; constrictive bronchiolitis; cryptogenic organizing pneumonia; bronchiolitis obliterans with organizing pneumonia (BOOP)