paraneoplastic acrokeratosis of Bazex; Bazex syndrome; acrokeratosis paraneoplastica

Etiology

• associated with squamous cell carcinoma
• upper respiratory system (head & neck cancer)
• esophageal cancer (squamous cell carcinoma)

Pathology

* histopathology images

Clinical manifestations

• psoriaform lesions of the hands, feet, ears & nose
• onychodystrophy
• keratoderma may also be present
  • hyperkeratotic plaques on the palms & soles with surrounding erythema
• evidence of malignancy may be noted

* images

Management

• effective treatment of the underlying malignancy results in resolution of the dermatosis

More general terms

• paraneoplastic dermatosis