prothrombin antibody in serum/plasma

Indications

• evaluation* of
  • antiphospholipid antibody syndrome
  • lupus anticoagulant
  • hypercoagulability

* Experimental, not proven clinical utility

Laboratory

• in vitro coagulation tests correct with addition of normal plasma because the autoantibody does not interact with the active site of an enzyme

Clinical significance

• occurs in association with
  • low-grade non-Hodgkin's lymphoma
  • chronic lymphocytic leukemia
• enhances clearance of factor II (prothrombin) from the circulation

More general terms

• serology
• clinical coagulation test

More specific terms

• prothrombin antibody IgG
• prothrombin antibody IgM

Additional terms

• coagulation factor II inhibitor in plasma
• prothrombin; coagulation factor II; contains: activation peptide fragment 1; activation peptide fragment 2; thrombin light chain; thrombin heavy chain (F2)