certolizumab pegol (Cimzia)

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Indications

* FDA-approved indications according to[2]

Contraindications

Pregnancy category: B[2]

Dosage

Monitor

Laboratory

Mechanism of action

Notes

Cost is about $1500 per month (same as Humira)

More general terms

References

  1. Prescriber's Letter 15(6): 2008 New Drug: Cimzia (Certolizumab Pegol) Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=240607&pb=PRL (subscription needed) http://www.prescribersletter.com
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Medical Knowledge Self Assessment Program (MKSAP) 16, 17, 18, 19. American College of Physicians, Philadelphia 2012, 2015, 2018, 2022.
  3. 3.0 3.1 Cimzia (certolizumab pegol) approved by the U.S. FDA for treatment of adult patients with active psoriatic arthritis. http://www.prnewswire.com/news-releases/cimzia-certolizumab-pegol-approved-by-the-us-fda-for-treatment-of-adult-patients-with-active-psoriatic-arthritis-225778051.html
  4. 4.0 4.1 Bankhead C American Academy of Dermatology Meeting Coverage 2017 Cimzia Passes Muster in Two Psoriasis Trials - Met primary efficacy goals versus placebo; third trial still to come. http://www.medpagetoday.com/MeetingCoverage/AAD/63625?xid=nl_mpt_DHE_2017-03-07&eun=g1094596d0r&pos=4
    Gottlieb AB, et al Certolizumab pegol treatment for chronic plaque psoriasis: 16-week primary results from two phase III, multicenter, randomized, placebo-controlled studies. American Academy of Dermatology (AAD) 2017; Abstract 5077.
  5. 5.0 5.1 5.2 Clowse MEB, Scheuerle AE, Chambers C et al. Pregnancy outcomes after exposure to certolizumab pegol: Updated results from a pharmacovigilance safety database. Arthritis Rheumatol 2018 Sep; 70:1399-1407 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29623679
  6. Cimzia Prescribing information http://www.cimzia.com/pdf/Prescribing_Information.pdf