coagulation factor V autoantibody

Etiology

• spontaneous (20%)
• exposure to bovine factor V present in topical thrombin or 'surgical glue' used in surgical procedures (80%)

Epidemiology

uncommon

Pathology

• heterologous antibodies to bovine factor V cross-react with human factor V
• serious, even fatal bleeding may occur

Laboratory

• prolongation of PT & aPTT; neither corrects with addition of normal plasma

More general terms

• autoantibody
• coagulation factor antibody

Additional terms

• coagulation factor V inhibitor in plasma
• coagulation factor V; activated protein C cofactor; proaccelerin, labile factor; contains: coagulation factor V heavy chain; coagulation factor V light chain (F5)