11-cis retinol dehydrogenase (11-cis RDH, RDH5, RDH1)

Function

• stereospecific 11-cis retinol dehydrogenase
• catalyzes the final step in the biosynthesis of 11-cis retinaldehyde
• retinoic acid biosynthesis, 1st (rate-limiting) step

retinol + NAD+ <--> retinal + NADH

Cofactor: NAD

Structure

• belongs to the short-chain dehydrogenases/reductases (SDR) family

Compartment

membrane

Expression

retinal pigment epithelium

Pathology

• defects in RDH5 are a cause of fundus albipunctatus

More general terms

• retinal dehydrogenase

Database

• OMIM: https://mirror.omim.org/entry/136880
• OMIM: https://mirror.omim.org/entry/601617
• UniProt: http://www.uniprot.org/uniprot/Q92781.html