11-beta hydroxysteroid dehydrogenase-2 (corticosteroid 11-beta-dehydrogenase isozyme 2, 11-DH2, 11-beta-hydroxysteroid dehydrogenase type 2, 11-beta-HSD2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, HSD11B2 HSD11K)

Function

• catalyzes conversion of cortisol to inactive metabolite cortisone
• modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids
• interacts with ligand-free cytoplasmic NR3C2

11-beta-hydroxysteroid + NAD+ <--> 11- oxosteroid + NADH

Inhibition:

• inhibited by glycyrrhetinic acid (derived from liquorice), carbenoloxone & 11-alpha-OH-progesterone

Structure

• belongs to the short-chain dehydrogenases/reductases (SDR) family

Compartment

microsome

Expression

• found in placenta, kidney, pancreas, prostate, ovary, small intestine & colon

Pathology

• defects in HSD11B2 are the cause of apparent mineralocorticoid excess

More general terms

• 11-OH steroid dehydrogenase; corticosteroid 11-beta dehydrogenase

Database

• OMIM: https://mirror.omim.org/entry/218030
• UniProt: http://www.uniprot.org/uniprot/P80365.html