cytosolic 10-formyltetrahydrofolate dehydrogenase; 10-FTHFDH; FDH; aldehyde dehydrogenase family 1 member L1 (ALDH1L1, FTHFD)

Function

-..........-

10-formyltetrahydrofolate  +  NADP+   + H2O .               <-->
tetrahydrofolate + CO2 + NADPH

Structure

• in the N-terminal section; belongs to the GART family
• in the C-terminal section; belongs to the aldehyde dehydrogenase family, ALDH1L subfamily
• contains 1 acyl carrier domain

Compartment

cytoplasm

Expression

• highly expressed in liver, pancreas & kidney

More general terms

• dehydrogenase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10840
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10840
• OMIM: https://mirror.omim.org/entry/600249
• UniProt: http://www.uniprot.org/uniprot/O75891.html