N-acetylated-alpha-linked acidic dipeptidase-like protein; NAALADase L; ileal dipeptidylpeptidase; 100 kD ileum brush border membrane protein; I100 (NAALADL1, NAALADASEL, NAALADL)

Function

• NAALADase-like activity unknown
• no NAAG hydrolyzing activity
• dipeptidyl-peptidase IV type activity
• cleaves Gly-Pro-AMC in vitro
• release of an unsubstituted, C-terminal glutamyl residue, generally from Ac-Asp-Glu or folylpoly-gamma glutamates

Cofactor:

• binds 2 Zn+2 per subunit

Structure

belongs to the peptidase M28 family, M28B subfamily

Compartment

• cell membrane, apical cell membrane
• ileal brush border membrane

Alternative splicing

named isoforms=8

Expression

• expressed in the distal small intestine
• also expressed in the spleen & testis
• weak expression in the brain, mainly brain stem, amygdala, thalamus, ventral striatum

More general terms

• dipeptidase
• glycoprotein
• metalloprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10004
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10004
• OMIM: https://mirror.omim.org/entry/602640
• UniProt: http://www.uniprot.org/uniprot/Q9UQQ1.html