1-acylglycerophosphocholine O-acyltransferase 1 (lung-type acyl-coa:lysophosphatidylcholine acyltransferase 1, acyltransferase-like 2, phosphonoformate immuno-associated protein 3, AYTL2, LPCAT1, PFAAP3)

Function

• acetyltransferase
• de novo phospholipid biosynthesis
• mediates convertion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine
• Ca+2-independent activity
• preference for saturated fatty acyl-CoAs, & 1-myristoyl or 1-palmitoyl LPC as acyl donors & acceptors, respectively
• may synthesize phosphatidylcholine in pulmonary surfactant thus a role in respiratory physiology

Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
                    <-->
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine

Structure

• belongs to 1-acyl-sn-glycerol-3-phosphate acyltransferase family
• contains 2 EF-hand domains
• HXXXXD motif is essential for acyltransferase activity & may constitute binding site for the phosphate moiety of glycerol-3-phosphocholine
• di-lysine motif confers endoplasmic reticulum localization for type 1 membrane proteins

Compartment

• endoplasmic reticulum membrane, Golgi membrane

More general terms

• acyltransferase

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NF37.html