1-acyl-sn-glycerol-3-phosphate acyltransferase eta; 1-AGP acyltransferase 7; 1-AGPAT 7, lysophosphatidic acid acyltransferase eta; LPAAT-eta; acyltransferase-like 3 (AGPAT7, LPCAT4, AYTL3)

Function

• converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (putative)
• de novo phospholipid biosynthesis, 2nd step

Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
               <-->
CoA + 1,2-diacyl-sn-glycerol 3-phosphate

Structure

• belongs to 1-acyl-sn-glycerol-3-phosphate acyltransferase family

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=3

Expression

• widely expressed
• expressed in uterus, thymus, pancreas, skeletal muscle, bladder, stomach, lung & testis

More general terms

• 1-acyl-sn-glycerol-3-phosphate acyltransferase

Database

• UniProt: http://www.uniprot.org/uniprot/Q643R3.html