1,4-dithiothreitol; 1,4-dimercapato-2,3-butanediol (DTT, Cleland's reagent)

Introduction

Used in vitro to reduce protein disulfides to thiols (cysteine residues). Product of dithiothreitol reduction of protein disulfides is a 6 membered ring, thus driving the reaction in the direction of protein thiols.

More general terms

• thiol; sulhydryl compound; mercaptan
• alcohol

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=161958
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=272126
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=31362
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3563
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=170245
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=838120
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=836372