1,25-dihydroxyvitamin D3 24-hydroxylase, mitochondrial; vitamin D3 24-hydroxylase; 24-OHase; cytochrome P450 24A1; P450-CC24 (CYP24A1, CYP24)

Function

• role in maintaining Ca+2 homeostasis
• catalyzes NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D3) & calcitriol
• the enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid
• also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D3-26,23-lactone

calcitriol + NADPH + O2 <--> calcitetrol + NADP+ + H2O

calcidiol + NADPH + O2 <--> secalciferol + NADP+ + H2O

Cofactor: heme group (putative)

Structure

belongs to the cytochrome P450 family

Compartment

mitochondria

More general terms

• steroid hydroxylase
• mitochondrial protein
• cytochrome P450

Database

• OMIM: https://mirror.omim.org/entry/126065
• UniProt: http://www.uniprot.org/uniprot/Q07973.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1591
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1591