1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; acireductone dioxygenase (Fe(2+)-requiring); ARD; Fe-ARD; membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1; MTCBP-1; submergence-induced protein-like factor; Sip-L (ADI1, MTCBP1, HMFT1638)

Function

• aci-reductone dioxygenase (ARD) activity
• catalyzes formation of formate & 2-keto-4-methylthiobutyrate from 1,2-dihydroxy-3-keto-5-methylthiopentene
• 5-methylthioadenosine (MTA) methionine salvage pathway (yeast)
• down-regulates cell migration mediated by MMP14

Cofactor:

• binds 1 Ni+2 per monomer, can also use other divalent metal cations

Structure

belongs to the acireductone dioxygenase (ARD) family

Compartment

• cell membrane, cytoplasmic side, nucleus
• localizes to plasma membrane when complexed to MMP14

Alternative splicing

named isoforms=2

Expression

• expressed in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle, kidney

Pathology

• necessary for hepatitis C virus replication in an otherwise non-permissive cell line

More general terms

• dioxygenase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55256
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55256
• OMIM: https://mirror.omim.org/entry/613400
• UniProt: http://www.uniprot.org/uniprot/Q9BV57.html