Surgical Trial In Intracerebral Hemorrhage (STICH)

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Introduction

1033 patients, median age 62, 27 countries

CT evidence of spontaneous supratentorial intracranial hemorrhage duration < 72 hours

Surgery vs conservative management

Results:

  • 140 of 529 patients randomized to conservative therapy under- went surgery because of deterioration
  • at 6 months, no difference in disability or survival between surgical & conservatively-treated groups
  • patients with hematomas < 1 cm from cortical surface are more likely to benefit from surgical intervention

More general terms

References

  1. Journal Watch 25(7):55, 2005 Mendelow AD, Gregson BA, Fernandes HM, Murray GD, Teasdale GM, Hope DT, Karimi A, Shaw MD, Barer DH; STICH investigators. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial. Lancet. 2005 Jan 29;365(9457):387-97. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15680453 Nakano T, Ohkuma H. Surgery versus conservative treatment for intracerebral haemorrhage--is there an end to the long controversy? Lancet. 2005 Jan 29;365(9457):361-2. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15680436